Balkrishen Bhat PhD

Int. Head of LNP Formulation

Dr. Balkrishen Bhat (Bal) has more than 25 years of experience in the discovery and development of nucleosides, oligonucleotides for antisense, RNAi, microNA, lncRNA and mRNA technologies for therapeutic applications. He served as Vice President and Head of Chemistry at Translate Bio (Sanofi) and RaNA Therapeutics where he built world class oligonucleotide synthesis capability and led the chemistry efforts in LNP and cell biased delivery systems. Prior to Translate Bio, Bal worked at Regulus Therapeutics as a Senior Director and Department Head of Chemistry. In this role he successfully built a robust oligonucleotide synthesis, analytical and bioanalytical capability and led the efforts in compound identification and optimization of microRNA modulators for therapeutics applications. Bal played a key role in the discovery and development of RG101 for the treatment of hepatitis C, RG012 for the treatment of Alport Syndrome and RG125 to treat NASH. Bal also led the efforts to develop new chemical entities and cell biased delivery systems including GalNAc conjugates to various cell and tissue types. Prior to Regulus, Bal spent 13 years at Isis/Ionis Pharmaceuticals where he held various positions including Director of Medicinal Chemistry. He played a key role in creating new chemical entities in the field of nucleosides, nucleotides and backbone modifications including bicyclic nucleic acids. Dr. Bhat has co-authored over 95 publications and is co-inventor of more than 100 patent applications (50 issued US patents). Dr. Bhat received his Ph.D. in Medicinal Chemistry from Central Drug Research Institute (CDRI) Lucknow India and postdoctoral fellowship at University of Illinois Urbana-Champaign.